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Index > Protein center > C3(Gene name) > Bovine
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  • C3 (Gene name),
  • Complement C3 (Protein name ),  CO3_BOVIN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    C3;
    Protein name:
    Complement C3;
    Alternative:

    Organism:
    Bovine (Bos taurus). 
    General Annotation
    Sub Unit:
    C3 precursor is first processed by the removal of 4 Arg residues, forming two chains, beta and alpha, linked by a disulfide bond. C3 convertase activates C3 by cleaving the alpha chain, releasing C3a anaphylatoxin and generating C3b (beta chain + alpha' chain). C3dg interacts with CR2 (via the N-terminal Sushi domains 1 and 2). Interacts with VSIG4 (By similarity). Interacts with bovine herpes virus 1 (BHV-1) envelope glycoprotein C; this interaction inhibits the activation of the complement system.
    Function:
    Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    1661
    Sequence:
    50:
    MKPTSGPSLL | LLLLASLPMA | LGNPMYSMIT | PNILRLESEE | TVVLEAHGGQ | 
    100:
    GTIQVSVTVH | DFPAKKQVLS | NENTQLNSNN | GYLSTVTIKI | PASKELKSDK | 
    150:
    GHKFVTVVAT | FGNVQVEKVV | LISLQSGYLF | IQTDKTIYTP | GSTVLYRVFT | 
    200:
    VDHKLLPVGQ | TVFITIETPD | GIPVKRDSKS | SQNQFGILTL | SWNIPELVNM | 
    250:
    GVWKIKAYYE | DSPQQVFSAE | FEVKEYVLPS | FEVQLEPEEK | FYYIDDPDGL | 
    300:
    KVNIIARFLY | GEQVDGTAFV | IFGVQDGDRR | ISLTHSLTRV | PINDGNGEAI | 
    350:
    LKRQVLLNGV | QPSRADALVG | KSIYVSATVI | LQSGSDMVEA | ERTGIPIVTS | 
    400:
    PYQIHFTKTP | KFFKPAMPFD | LMVYVTNPDG | SPARHIPVVT | QGSNVQSLTQ | 
    450:
    DDGVAKLSIN | TQNKRDPLTI | TVRTKKDNIP | EGRQATRTMQ | ALPYNTQGNS | 
    500:
    NNYLHLSVPR | VELKPGETLN | VNFHLRTDPG | EQAKIRYYTY | MIMNKGKLLK | 
    550:
    VGRQYREPGQ | DLVVLPLTIT | SDFIPSFRLV | AYYTLINAKG | QREVVADSVW | 
    600:
    VDVKDSCMGT | LVVKNGGKEE | KHHRPGQQIT | LKIEADQGAR | VGLVAVDKGV | 
    650:
    FVLNKKNKLT | QRKIWDVVEK | ADIGCTPGSG | RNYAGVFTDA | GLTLKTSQGL | 
    700:
    ETQQRADPQC | PQPATRRRRS | VQLMEKRMDK | AGQYSSDLRK | CCEDGMRDNP | 
    750:
    MKFPCQRRAQ | FILQGDACVK | AFLDCCEYIT | QLRQQHSRDG | ALELARSDLD | 
    800:
    DDIIPEEDII | SRSQFPESWL | WTVIEDLKQA | DKNGISTKLM | NVFLKDSITT | 
    850:
    WEILAVSLSD | KKGICVADPY | EVTVMQDFFI | DLRLPYSVVR | NEQVEIRAIL | 
    900:
    YNYREAENLK | VRVELLYNPA | FCSLATAKKR | HQQTITIPAR | SSVAVPYVIV | 
    950:
    PLKIGLHEVE | VKAAVYNHFI | SDGVKKTLKV | VPEGVRVNKT | VAVRTLNPEH | 
    1000:
    LGQGGVQREE | VPAADLSDQV | PDTESETKIL | LQGTPVAQMT | EDAIDGERLK | 
    1050:
    HLIQTPSGCG | EQNMIGMTPT | VIAVHYLDST | DQWEKFGLEK | RQESLELIRK | 
    1100:
    GYTQQLAFRQ | KSSAYAAFQY | RPPSTWLTAY | VVKVFALAAN | LIAIDSKDLC | 
    1150:
    ETVKWLILEK | QKPDGIFQED | GPVIHQEMIG | GFRDTREKDV | SLTAFVLIAL | 
    1200:
    HEAKDICEAQ | VNSLGRSIAK | AGDFLENHYR | ELRRPYTVAI | AAYALALLGK | 
    1250:
    LEGDRLTKFL | NTAKEKNRWE | EPNQKLYNVE | ATSYALLALL | ARKDYDTTPP | 
    1300:
    VVRWLNEQRY | YGGGYGSTQA | TFMVFQALAQ | YQKDVPDHKE | LNLDVSIQLP | 
    1350:
    SRNSAVRHRI | LWESASLLRS | EETKENERFT | VKAEGKGQGT | LSVVTVYHAK | 
    1400:
    LKGKVSCKKF | DLRVSIRPAP | ETVKKPQDAK | GSMILDICTK | YLGDQDATMS | 
    1450:
    ILDISMMTGF | SPDVEDLKTL | STGVDRYISK | YEMNRDSNKN | TLIIYLDKVS | 
    1500:
    HTVEDCLSFK | VHQYFNVGLI | QPGAVKVYSY | YNLDETCIRF | YHPDKEDGML | 
    1550:
    SKLCHKDTCR | CAEENCFMHH | TEKEVTLEDR | LDKACEPGVD | YVYKTRLIQK | 
    1600:
    KLEDDFDEYI | MVIENIIKSG | SDEVQVKQER | KFISHIKCRE | ALKLKEGAHY | 
    1650:
    LVWGVSSDLW | GEKPKISYII | GKDTWVELWP | EAEECQDEEN | QKQCEDLANF | 
    1661:
    TENMVVFGCP | N
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Bovine Complement C3
    Cat.:
    E0861h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Bovine Complement C3
    Cat.:
    E0861m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Bovine Complement C3
    MSDS:
    Please sign in first.
    ELISA Kit for Bovine Complement C3
    Cat.:
    E0861r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Bovine Complement C3
    Cat.:
    E0861b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Bovine Complement C3
    MSDS:
    Please sign in first.
    CLIA Kit for Bovine Complement C3
    Cat.:
    U0861b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Bovine Complement C3
    MSDS:
    Please sign in first.
    CLIA Kit for Bovine Complement C3
    Cat.:
    U0861r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Bovine Complement C3
    MSDS:
    Please sign in first.
    CLIA Kit for Bovine Complement C3
    Cat.:
    U0861m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Bovine Complement C3
    Cat.:
    U0861h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Bovine Complement C3
    Polyclonal Antibody for Bovine Complement C3
    Polyclonal Antibody for Bovine Complement C3
    Cat.:
    P0861Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Bovine Complement C3
    Cat.:
    P0861Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Bovine Complement C3
    Polyclonal Antibody for Bovine Complement C3
    Cat.:
    P0861Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Bovine Complement C3
    Monoclonal Antibody for Bovine Complement C3
    Monoclonal Antibody for Bovine Complement C3
    Monoclonal Antibody for Bovine Complement C3
    Monoclonal Antibody for Bovine Complement C3
    Monoclonal Antibody for Bovine Complement C3
    Protein for Bovine Complement C3
    Protein for Bovine Complement C3
    Cat.:
    R0861h
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%
    Protein for Bovine Complement C3
    Protein for Bovine Complement C3
    Protein for Bovine Complement C3
    Protein for Bovine Complement C3

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    Precision
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    References
    1. 1.
      "The structure of bovine complement component 3 reveals the basis for thioester function."
      Fredslund F. , Jenner L. , Husted L.B. , Nyborg J. , Andersen G.R. , Sottrup-Jensen L.
      J. Mol. Biol.361:115-127(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF C3
    2. 2.
      NIH - Mammalian Gene Collection (MGC) project
      Submitted (2006-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: Crossbred X Angus.
      tissue: Liver.
    3. 3.
      "Species selective interaction of Alphaherpesvirinae with the 'unspecific' immune system of the host."
      Huemer H.P. , Larcher C. , van Drunen Littel-van den Hurk S. , Babiuk L.A.
      Arch. Virol.130:353-364(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BHV-1 GLYCOPROTEIN C
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